Laboratory Medicine

Test catalogue

Cyclosporine
Test Name Cyclosporine (Trough, Peak, Random)
Specimen Type / Requirements Container Type = Lavender (EDTA) Minimum Testing Volume = 1 mL Whole Blood Tube should be fill to at least ½ or greater of its vacuum capacity
Specimen Handling Collection Instructions: Collect sample in lavender top (EDTA). Whole blood is preferred. Include time of dose and time of collection. Trough: Collect just before next dose is administered. Peak: Collect at peak 2 hours after completion of administration of drug. Stability: Stable for up to 14 days at 15-25◦C and 2-8◦C or 6 months at -20◦C Transportation: Transport at room temperature ASAP. Laboratory Staff Instructions: Specimens must be mixed thoroughly after thawing and before testing to ensure consistency of results Sample Rejection Criteria: Serum, plasma or clotted specimens unacceptable. Specimens left at room temperature for >24h.
Required Documentation
Turnaround Time (TAT) 1 Day	Test Utilization
Reference Value Trough: 150 – 400 ug/L Peak: No definitive therapeutic or toxic ranges have been established. Suggested guideline for cyclosporine 2h post-dose: 300 – 1,100 ng/mL. Random: Time of dose in relation to collection time of sample unknown. No definitive therapeutic or toxic ranges have been established. Target therapeutic range may vary depending on type of transplant, treatment protocols, and time post-transplant. Interpret results using this information and any clinical signs and symptoms of rejection or toxicity.
Test Code CYSPR	Methodology Competitive Binding Immunoassay
Testing Location SMH-Biochemistry	Other Information Last Updated: July 14 2026

Cyclosporine

Test Name

Cyclosporine (Trough, Peak, Random)

Specimen Type / Requirements

Container Type = Lavender (EDTA)

Minimum Testing Volume = 1 mL Whole Blood

Tube should be fill to at least ½ or greater of its vacuum capacity

Specimen Handling

Collection Instructions: Collect sample in lavender top (EDTA). Whole blood is preferred. Include time of dose and time of collection.

Trough: Collect just before next dose is administered.

Peak: Collect at peak 2 hours after completion of administration of drug.

Stability: Stable for up to 14 days at 15-25◦C and 2-8◦C or 6 months at -20◦C

Transportation: Transport at room temperature ASAP.

Laboratory Staff Instructions: Specimens must be mixed thoroughly after thawing and before testing to ensure consistency of results

Sample Rejection Criteria: Serum, plasma or clotted specimens unacceptable. Specimens left at room temperature for >24h.

Required Documentation

Turnaround Time (TAT)

1 Day

Test Utilization

Reference Value

Trough: 150 – 400 ug/L

Peak: No definitive therapeutic or toxic ranges have been established. Suggested guideline for cyclosporine 2h post-dose: 300 – 1,100 ng/mL.

Random: Time of dose in relation to collection time of sample unknown. No definitive therapeutic or toxic ranges have been established.

Target therapeutic range may vary depending on type of transplant, treatment protocols, and time post-transplant. Interpret results using this information and any clinical signs and symptoms of rejection or toxicity.

Test Code

CYSPR

Methodology

Competitive Binding Immunoassay

Testing Location

SMH-Biochemistry

Other Information

Last Updated: July 14 2026