Laboratory Medicine

Test Catalogue

Clozapine and Metabolite
Test Name Clozapine and Metabolite
Specimen Type/Requirements Container Type = 1 Red Top Minimum Testing Volume = 1mL Blood Tube must fill to at least ½ or greater of its vacuum capacity
Specimen Handling Collection Instructions: Collect sample in red top tube. Avoid gel-separator tube. Submit trough specimen (i.e., collected immediately before next dose). Write your initials, date and time of collection on the collection label. Laboratory Staff Instructions: Separate samples from cells as soon as possible. Stability: Separated from cells stable at room temperature for 7 days, refrigerated 28 days, frozen for 28 days. Rejection Criteria: Unlabeled or samples of non-sufficient quantity. Transportation: Send sample to core lab as soon as possible or ship frozen if transporting from an outside lab.
Required Documentation
Turnaround Time (TAT) 7 days (batched)	Test Utilization
Reference Value Clozapine Therapeutic: : 350 – 600 ng/mL Toxic : >1000 ng/mL Norclozapine Not established Some individuals may show therapeutic response outside this range, or may display toxicity within the therapeutic range; interpretation should include clinical evaluation. Please note that this test is NOT a replacement for hematological (white blood cell and absolute neutrophil count) monitoring.
Test Code CLOZC	Methodology LC-MS/MS
Testing Location SMH-Biochemistry	Other Information Last Updated: January 06, 2023

Clozapine and Metabolite

Test Name

Clozapine and Metabolite

Specimen Type/Requirements

Container Type = 1 Red Top

Minimum Testing Volume = 1mL Blood

Tube must fill to at least ½ or greater of its vacuum capacity

Specimen Handling

Collection Instructions: Collect sample in red top tube. Avoid gel-separator tube. Submit trough specimen (i.e., collected immediately before next dose). Write your initials, date and time of collection on the collection label.

Laboratory Staff Instructions: Separate samples from cells as soon as possible.

Stability: Separated from cells stable at room temperature for 7 days, refrigerated 28 days, frozen for 28 days.

Rejection Criteria: Unlabeled or samples of non-sufficient quantity.

Transportation: Send sample to core lab as soon as possible or ship frozen if transporting from an outside lab.

Required Documentation

Turnaround Time (TAT)

7 days (batched)

Test Utilization

Reference Value

Clozapine
Therapeutic: : 350 – 600 ng/mL
Toxic : >1000 ng/mL

Norclozapine
Not established

Some individuals may show therapeutic response outside this range, or may display toxicity within the therapeutic range; interpretation should include clinical evaluation.

Please note that this test is NOT a replacement for hematological (white blood cell and absolute neutrophil count) monitoring.

Test Code

CLOZC

Methodology

LC-MS/MS

Testing Location

SMH-Biochemistry

Other Information

Last Updated: January 06, 2023