Laboratory Medicine

Test Catalogue

Amitriptyline
Test Name Amitritypline (Elavil \| Tryptanol \| Endep \| Tryptizol \| Laroxyl \| Trepiline \| Saroten \| Triptyl \| Redomex)
Specimen Type/Requirements Container Type = 1 Red Top Minimum Testing Volume = 3mL Blood Tube must fill to at least ½ or greater of its vacuum capacity
Specimen Handling Collection Instructions: Collect sample in red top tube. Avoid gold top (SST). Collect at steady state. To monitor therapy, draw trough specimen prior to morning dose or 10-12 h after last drug administration. This assay includes Amitriptyline and Nortriptyline. Note date and time of collection and last dose. Laboratory Staff Instructions: Separate samples from cells as soon as possible. Repeated freezing and thawing of samples should be avoided Rejection Criteria: Gel separator, grossly hemolyzed and icteric samples, Unlabeled or Not Sufficient Quantity samples will be rejected. Stability: Separated from cells stable at room temperature for 5 days, refrigerated 2 weeks, frozen 6 months. Transportation: Send to Core Lab as soon as possible
Required Documentation
Turnaround Time (TAT) 7 days (batched)	Test Utilization
Reference Value Combined Metabolite: 80-200 ng/mL Toxic : >300 ng/mL
Test Code AMNOR	Methodology LCMS (Liquid Chromatography/Mass Spectrometry)
Testing Location SMH-Biochemistry	Other Information Last Updated: November 03, 2022

Amitriptyline

Test Name

Specimen Type/Requirements

Container Type = 1 Red Top

Minimum Testing Volume = 3mL Blood

Tube must fill to at least ½ or greater of its vacuum capacity

Specimen Handling

Collection Instructions: Collect sample in red top tube. Avoid gold top (SST). Collect at steady state. To monitor therapy, draw trough specimen prior to morning dose or 10-12 h after last drug administration. This assay includes Amitriptyline and Nortriptyline. Note date and time of collection and last dose.

Laboratory Staff Instructions: Separate samples from cells as soon as possible. Repeated freezing and thawing of samples should be avoided

Rejection Criteria: Gel separator, grossly hemolyzed and icteric samples, Unlabeled or Not Sufficient Quantity samples will be rejected.

Stability: Separated from cells stable at room temperature for 5 days, refrigerated 2 weeks, frozen 6 months.

Transportation: Send to Core Lab as soon as possible

Required Documentation

Turnaround Time (TAT)

7 days (batched)

Test Utilization

Reference Value

Combined Metabolite: 80-200 ng/mL

Toxic : >300 ng/mL

Test Code

AMNOR

Methodology

LCMS (Liquid Chromatography/Mass Spectrometry)

Testing Location

SMH-Biochemistry

Other Information

Last Updated: November 03, 2022