Critical Care


Our goal is to develop research in critical care from basic to clinical level and to enhance translational research. Clinical research labs facilitate clinical research in a similar model as other Hospital labs. Our activities include research in biomedical and information technologies, and we also provide education for young researchers from national and international origins.

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About Research

Research is a priority of the critical care and anesthesia departments of St. Michael's Hospital.

We conduct research in different fields of intensive care, including ventilator lung injury research, brain ischaemia and the consequences of brain injury on neurological metabolizing and specific brain structures. Current studies focus on sepsis, new modes of ventilation support, post-injury brain protection and cardiac function during and after surgery.

The links between basic and clinical research have become a reality in critical care. Emerging researchers are developing translational research and implementing new concepts and methods. In cardiology, the focus has been on the pathophysiology of oxygen metabolism and organ preservation during and after cardiac surgery.

Bench to Bed Research

The integration of comprehensive experimental laboratory with an active clinical research program has provided opportunities for true bench to bedside research. Previous studies have evaluated mechanisms for perioperative cardiac and neurologic protection, the use transesophageal echocardiography in assessment of the critically ill and the effects of alkali therapy on ischemic and hypoxic myocardium. Recent work focuses on the safety and efficacy of a new class of red blood cell substitutes, both in the laboratory and in clinical settings.

Current studies help to define the molecular biology and pattern of gene expression related to anemia, hypoxia and cardiopulmonary bypass. St. Michael’s Fellows participating in research are offered the opportunity to gain experience in a broad range of subjects, to evaluate of new technologies and to participate in large clinical trials.

Lastly, collaborative research is well integrated by the critical care department with specialties such as cardiology, respirology, nephrology, gastroenterology, endocrinology and nutrition.